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The Antoine River is a tributary of the Little Missouri River in southwestern Arkansas in the United States. Via the Little Missouri, Ouachita and Red Rivers, it is part of the watershed of the Mississippi River. According to GNIS, it has also been known as Antoine Creek. A short headwater tributary of the river is known as the Little Antoine River. The Antoine River rises in northeastern Pike County about 10 mi (16 km) west-southwest of Amity and flows generally south-southeastwardly, past the town of Antoine. For most of its course the river is used to define the boundary between Pike and Clark Counties. It joins the Little Missouri River about 3 mi (5 km) southwest of Okolona. This river is a good fishing river, with bluegill, trout, catfish, crappie, bass, being just a few.